Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblasts reveals shared allelic effects between Latin American and European ancestries.

doi:10.1186/s12864-026-13065-3

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Article

Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblasts reveals shared allelic effects between Latin American and European ancestries.

BMC genomics - 24 Jun 2026

Boltz Toni A, Bot Merel, Lapinska Sandra, Schwarz Tommer, Hou Kangcheng, Garske Kristina M, Freund Malika K, Bearden Carrie E, Macaya Gabriel, Lopez-Jaramillo Carlos, Freimer Nelson, Boks Marco P, Kahn Rene S, Pasaniuc Bogdan, Ophoff Roel A

Abstract excerpt

BACKGROUND: Quantitative Trait Locus (QTL) analysis of molecular data has identified genetic variants associated with traits such as gene expression, and colocalization of these functional QTL with GWAS risk loci has offered insights into the genetic basis of human disease. We employed gene expression (RNA-seq) and chromatin accessibility (ATAC-seq) obtained from human primary fibroblasts to investigate...

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Topics

Humans
Alleles
Chromatin
Chromosome Mapping
European People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fibroblasts

Genome-Wide Association Study

Latin America

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Netherlands

Colombia

Costa Rica

South American People

Central American People

Source

Open in PubMed Open full text

Identifiers

PMID: 42343218
DOI: 10.1186/s12864-026-13065-3
PMCID: PMC13551787

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