Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Profiling of desmoid tumors reveals frequent mutations in chromatin-remodeling genes and identifies an Immune-myogenic subtype.

European journal of cancer (Oxford, England : 1990) - 26 Aug 2026

Gantzer Justine, Lu Xiaofan, Weingertner Noëlle, Fattori Antonin, Chenard Marie-Pierre, Plassard Damien, El Amri Amal, Sauleau Erik-A, Gangi Afshin, Kurtz Jean-Emmanuel, Malouf Gabriel G

Abstract excerpt

INTRODUCTION: Desmoid tumors (DTs) are locally aggressive soft tissue neoplasms with variable clinical behavior and limited therapeutic biomarkers. While CTNNB1 and APC mutations are known, the broader genomic, transcriptomic, and epigenetic features remain incompletely understood. METHODS: We performed integrated genomic, transcriptomic, and DNA methylation profiling on 76 DTs, including post-treatment samples....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Desmoid Tumors

Share to DNA Methylation

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Transcriptome

Source

Identifiers

PMID: 42341616
DOI: 10.1016/j.ejca.2026.116905

Genes

APC
CTNNB1
CD274
CTLA4
KMT2C
PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Profiling of desmoid tumors reveals frequent mutations in chromatin-remodeling genes and identifies an Immune-myogenic subtype.PMID 42341616Read ↗

Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypesSemantic proximity Read ↗

Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilitiesSemantic proximity Read ↗

Integrated genetic and epigenetic analysis of myxofibrosarcoma.Semantic proximity Read ↗

Multi-site desmoplastic small round cell tumors are genetically related and immune-coldSemantic proximity Read ↗

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.Semantic proximity Read ↗

The immune subtypes and landscape of sarcomasSemantic proximity Read ↗

Genomic Landscape of Superficial Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read ↗

Immune checkpoint inhibitor response in sarcomas associates with immune infiltrates and increased expression of transposable elements and viral response pathwaysSemantic proximity Read ↗

Novel enriched pathways in superficial malignant peripheral nerve sheath tumours and spindle/desmoplastic melanomas.Semantic proximity Read ↗

Whole-Genome and Transcriptome Sequencing Identified NOTCH2 and HES1 as Potential Markers of Response to Imatinib in Desmoid Tumor (Aggressive Fibromatosis): A Phase II Trial Study.Semantic proximity Read ↗

Multiomics profiling reveals excessive fibroblast activation and collagen deposition are associated with poor prognosis in desmoid tumorsSemantic proximity Read ↗

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.