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Article

Genomic Landscape of Superficial Malignant Peripheral Nerve Sheath Tumor.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2025

McAfee John L, Alban Tyler J, Makarov Vladimir, Rupani Amit, Parthasarathy Prerana B, Tu Zheng, Ronen Shira, Billings Steven D, Diaz C Marcela, Chan Timothy A, Ko Jennifer S

Abstract excerpt

Superficial malignant peripheral nerve sheath tumors (SF-MPNSTs) are rare cancers and can be difficult to distinguish from spindle cell (SCM) or desmoplastic (DM) melanomas. Their biology is poorly understood. We performed whole-exome sequencing and RNA sequencing (RNA-seq) on SF-MPNST (n = 8) and compared them with cases of SCM (n = 7), DM (n = 8), and deep MPNST (D-MPNST, n = 8). Immunohistochemical staining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39532239
DOI: 10.1016/j.labinv.2024.102183

Genes

PRAME
CALB2
MLPH
PLCH1
SOX11
SOX8
TBX4

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