Article
Novel enriched pathways in superficial malignant peripheral nerve sheath tumours and spindle/desmoplastic melanomas.
The Journal of pathology - 1 Jan 2018
Jour George, Andeen Nicole K, Al-Rohil Rami, Aung Phyu P, Mehrotra Meenakshi, Duose Dzifa, Hoch Benjamin, Argenyi Zolt, Luthra Rajyalakshmi, Wistuba Ignacio I, Prieto Victor G
Abstract excerpt
Superficial malignant peripheral nerve sheath tumour (MPNST) is a rare, soft tissue neoplasm that shares morphological features and some molecular events with spindle/desmoplastic melanoma (SDM). Herein, we sought to identify molecular targets for therapy by using targeted RNA/DNA sequencing and gene expression of key immunological players. DNA and RNA from formalin-fixed paraffin-embedded tissue were extracted...
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