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Multi-site desmoplastic small round cell tumors are genetically related and immune-cold

4 Apr 2022

Abstract excerpt

Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue sarcoma that is characterized by the EWSR1-WT1 fusion protein. Patients present with hundreds of tumor implants in their abdominal cavity at various sites. To determine the genetic relatedness among these sites, exome and RNA sequencing were performed on 22 DSRCT specimens from 14 patients, four of whom had specimens from various...

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PMID: 35379887
DOI: 10.1038/s41698-022-00257-9

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