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Article

Global and regional DNA methylation patterns in heart failure: a case-control analysis.

EBioMedicine - 1 Jul 2026

Krolevets Mykhailo, Cate Vincent Ten, Prochaska Jürgen H, Schulz Andreas, Rapp Steffen, Zeid Silav, Tenzer Stefan, Andrade-Navarro Miguel A, Lu Ake, Strauch Konstantin, Schuster Alexander K, Beutel Manfred E, Heinrich Isabel, Weinmann-Menke Julia, Lackner Karl J, Lurz Philipp, Horvath Steve, Niehrs Christof, Wild Philipp S

Abstract excerpt

BACKGROUND: Heart failure (HF) is a syndrome of heterogeneous aetiology and multiple exposomal causes. The role of DNA methylation (DNAm) changes in symptomatic HF and its phenotypes is unclear. This work addresses global and regional DNAm patterns and epigenetic ageing in HF. METHODS: Patients with HF were included from the MyoVasc Study, an investigator-initiated prospective cohort study. Individuals without HF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42335675
DOI: 10.1016/j.ebiom.2026.106340
PMCID: PMC13316289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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