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Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure

22 May 2025

Abstract excerpt

BACKGROUND: Methylation of RNA is involved in many pathophysiological processes. The roles of N6-methyladenosine (m6A) and N7-methylguanosine (m7G) in heart failure (HF) have been established. However, the impact of 5-methylcytosine (m5C) on HF and its relationship with the immune microenvironment (IME) remains elusive. METHODS: GSE141910 (200 HF, 166 NFDs) was used as training cohort. Focusing on 9 identified...

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PMID: 40405297
DOI: 10.1186/s41065-025-00454-z

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