Article
NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.
Cell genomics - 8 Jul 2026
Nazeen Sumaiya, Wang Xinyuan, Morrow Autumn R, Strom Ronya, Ethier Elizabeth, Ritter Dylan, Henderson Alexander B H, Afroz Jalwa, Cassa Christopher S, Stitziel Nathan O, Gupta Rajat M, Luk Kelvin C, Studer Lorenz, Khurana Vikram, Sunyaev Shamil R
Abstract excerpt
Studying the genetic basis of human phenotypes involves two primary strategies. Model-system experiments generate interpretable gene networks but do not establish relevance to human disease. In contrast, statistical genetics identifies variant- and gene-level associations but cannot test mechanistic models. Here, we bridge these approaches by introducing NERINE, a hierarchical model-based rare variant association...
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