Article

NERINE reveals rare variant associations in gene networks across phenotypes and implicates an <i>SNCA-PRL-LRRK2</i> subnetwork in Parkinson’s disease

2025-01-10

Abstract excerpt

There are two primary approaches to study the genetic basis of human phenotypes. Experiments in model systems generate interpretable gene networks but, in isolation, do not establish relevance to the human condition. Statistical genetics identifies relevant association signals at the variant or gene level but lacks tools to test specific mechanistic models, as existing methods do not incorporate the topology of ge...

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Literature Corpus work: 0aa60479-13fe-54d9-bff5-8c039aed9f7b
DOI: 10.1101/2025.01.07.631688

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