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Article

Novel Insight into the Therapeutic Targets for Spinal Degenerative Diseases Gained by a Post-Genome-Wide Association Study.

International journal of medical sciences - 1 Jan 2026

Zhao Xuan, Wang Qijun, Wang Chunjie, Huang Haixia, Wang Peng, Wang Wei, Lu Jie, Lu Shibao

Abstract excerpt

Degenerative spinal diseases are a group of conditions that affect the structure and function of the spine, which can severely impact patient prognosis. Elucidating the druggable genes governing degenerative spinal diseases plays a pivotal role. GWAS data on degenerative spinal diseases, druggable genes, and eQTL data were acquired and Mendelian Randomization (MR) analysis was conducted. Colocalization analysis...

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Source

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Identifiers

PMID: 42328112
DOI: 10.7150/ijms.127489
PMCID: PMC13280751

Genes

PAK4
ESR1
PI4KB
GPX1
KLRC2
SORCS2
TCF19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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