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Article

GFPT1 as a cross-ancestry validated target for degenerative spinal disease: genetic association in a Chinese cohort and functional characterization in zebrafish.

Communications biology - 2 Jun 2026

Yang Bo, Li Feng, Zhang Yongsen, Zhang Fan, Wang Zhihao, Da Yifeng, Yang Xuejun, Xing Wenhua, Tian Jing

Abstract excerpt

Degenerative spinal disease (DSD), including spinal stenosis and spondylosis, lacks effective pharmacological treatment. To identify druggable targets and assess cross-ancestry applicability, we integrate multi-omics analyses using Summary-data-based Mendelian Randomization (SMR), colocalization, and two-sample Mendelian randomization with European whole-blood, peripheral-blood, and CSF eQTL/pQTL datasets,...

Read the complete abstract on PubMed

Topics

Animals
Humans
Asian People
China
Cohort Studies
Genetic Association Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Quantitative Trait Loci

Spinal Stenosis

Zebrafish

Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42230780
DOI: 10.1038/s42003-026-10320-x
PMCID: PMC13529804

Genes

GFPT1
GPX1
SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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