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Article

The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease.

Annual review of genomics and human genetics - 1 Jan 2013

Ikegawa Shiro

Abstract excerpt

Degenerative skeletal disorders are common and serious problems worldwide, especially in aging populations. They are polygenic diseases influenced by both genetic and environmental factors, and hence the identification of susceptibility genes may provide clues to their etiology and pathogenesis, although this is still in its early stages. This review focuses on genetic studies of two representative degenerative...

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Topics

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Share to Extracellular Matrix Proteins
Share to GDF5 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Differentiation Factor 5

Share to Intervertebral Disc Degeneration

Share to Osteoarthritis

Share to Polymorphism, Single Nucleotide

Share to Spine and Intervertebral Disc Pathology

Source

Identifiers

PMID: 24003854
DOI: 10.1146/annurev-genom-091212-153427

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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