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The identification of novel gene mutations for degenerative lumbar spinal stenosis using whole-exome sequencing in a Chinese cohort.

BMC medical genomics - 21 May 2021

Jiang Xin, Chen Dong

Abstract excerpt

BACKGROUND: Degenerative lumbar spinal stenosis (DLSS) is a common lumbar disease that requires surgery. Previous studies have indicated that genetic mutations are implicated in DLSS. However, studies on specific gene mutations are scarce. Whole-exome sequencing (WES) is a valuable research tool that identifies disease-causing genes and could become an effective strategy to investigate DLSS pathogenesis. METHODS:...

Topics

Aged
Female
Humans
Male
Middle Aged
Asian People
Case-Control Studies
China
Cohort Studies
Exome Sequencing
Genetic Predisposition to Disease
Lumbar Vertebrae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymorphism, Single Nucleotide

Spinal Stenosis

Source

Open in PubMed Open full text

Identifiers

PMID: 34020649
DOI: 10.1186/s12920-021-00981-4
PMCID: PMC8138972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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