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mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

4 Oct 2020

Abstract excerpt

BACKGROUNDTherapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have demonstrated that T cells recognizing neoantigens are present in most cancers and offer a specific and highly immunogenic target for personalized vaccination.METHODSWe...

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PMID: 33016924
DOI: 10.1172/jci134915

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