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Vaccines for immunoprevention of DNA mismatch repair deficient cancers

1 Jun 2022

Abstract excerpt

The development of cancer vaccines to induce tumor-antigen specific immune responses was sparked by the identification of antigens specific to or overexpressed in cancer cells. However, weak immunogenicity and the mutational heterogeneity in many cancers have dampened cancer vaccine successes. With increasing information about mutational landscapes of cancers, mutational neoantigens can be predicted...

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PMID: 35732349
DOI: 10.1136/jitc-2021-004416

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