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Article

Mutant huntingtin disrupts TET1 transcription and alters DNA methylation in a Huntington's disease knock-in pig model.

Cell reports - 28 Jul 2026

Xie Leijie, Liu Xiaodong, Zhang Can, Niu Xinyi, Chen Laiqiang, Zhou Gongke, Zhu Mingyang, Li Caijuan, Tong Huichun, Yan Sen, Li Xiao-Jiang, Li Shihua, Lin Li

Abstract excerpt

Abnormal DNA methylation occurs in Huntington's disease (HD, but the underlying mechanisms remain unclear. Using a knock-in pig model, we identify significant alterations in 5mC and 5hmC levels linked to neural genes. TET1, which converts 5mC to 5hmC, decreases prior to symptom onset in pigs-a change not observed in HD mice. TBP binding sites are abundant in the porcine and human TET1 promoter, but scarce in...

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Share to 5-Methylcytosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42322611
DOI: 10.1016/j.celrep.2026.117584

Genes

TET1
TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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