Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

doi:10.1159/000443665

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Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

Neuro-degenerative diseases - 1 Jan 2016

Macakova Monika, Bohuslavova Bozena, Vochozkova Petra, Pavlok Antonin, Sedlackova Miroslava, Vidinska Daniela, Vochyanova Klara, Liskova Irena, Valekova Ivona, Baxa Monika, Ellederova Zdenka, Klima Jiri, Juhas Stefan, Juhasova Jana, Klouckova Jana, Haluzik Martin, Klempir Jiri, Hansikova Hana, Spacilova Jana, Collins Ryan, Blumenthal Ian, Talkowski Michael, Gusella James F, Howland David S, DiFiglia Marian, Motlik Jan

Abstract excerpt

BACKGROUND: Huntington's disease is induced by CAG expansion in a single gene coding the huntingtin protein. The mutated huntingtin (mtHtt) primarily causes degeneration of neurons in the brain, but it also affects peripheral tissues, including testes. OBJECTIVE: We studied sperm and testes of transgenic boars expressing the N-terminal region of human mtHtt. METHODS: In this study, measures of reproductive...

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PMID: 26959244
DOI: 10.1159/000443665

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