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Article

Integrative genomic characterization of the FADS1-2-3 mood disorder risk locus: implications for the role of polyunsaturated fatty acids.

Journal of affective disorders - 1 Nov 2026

Stacey David, Reay William R, Veltman Liam J, Benyamin Beben, Lee S Hong, Hyppönen Elina

Abstract excerpt

BACKGROUND: Polyunsaturated fatty acids (PUFA) have been implicated in mood disorder pathophysiology, with Mendelian randomisation studies suggesting a causal role. However, much of this evidence centres on the highly pleiotropic FADS1-2-3 gene cluster, raising concerns about horizontal pleiotropy and uncertainty regarding the true effector gene(s). To assess the validity of these concerns, we performed...

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Source

Identifiers

PMID: 42309192
DOI: 10.1016/j.jad.2026.122140

Genes

FADS1
FADS2
FADS3
TMEM258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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