Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative Multiomics Analysis Identifies DKK3 as a Germline Susceptibility-Related Regulator of Risperidone Response and Metabolic Risk in Schizophrenia.

Human mutation - 1 Jan 2026

Zhang Xiaoyun, Li Jingjing, Sun Yao, Hei Gangrui, Song Xueqin

Abstract excerpt

Background: Risperidone is a widely used second-generation antipsychotic for schizophrenia, known for its clinical efficacy but also for long-term metabolic side effects, including weight gain and glucose-lipid dysregulation. Although its therapeutic effects have been well characterized, the molecular basis linking its benefits and adverse metabolic outcomes remains poorly understood. Methods: To identify genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Germ-Line Mutation

Share to Intercellular Signaling Peptides and Proteins

Share to Multiomics

Share to Risperidone

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 42317215
DOI: 10.1155/humu/8434158
PMCID: PMC13273393

Genes

DKK3
EEF1A1
PRKAA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative Multiomics Analysis Identifies DKK3 as a Germline Susceptibility-Related Regulator of Risperidone Response and Metabolic Risk in Schizophrenia.PMID 42317215Read ↗

Assessing Genetic Risk of DKK3 and SLAMF6 in Erectile Dysfunction: A Comprehensive Analysis Based on Mendelian Randomization.Semantic proximity Read ↗

Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second-Generation Antipsychotics (SGA)-Induced Metabolic Syndrome (MetS).Semantic proximity Read ↗

Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.Semantic proximity Read ↗

Integrating Genome-wide and Epigenome-wide Associations for Antipsychotic Induced Extrapyramidal Side EffectsSemantic proximity Read ↗

Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic ApproachSemantic proximity Read ↗

Lipid-lowering and glucose-lowering drug targets differentially modulate antipsychotic treatment efficacy in schizophrenia.Semantic proximity Read ↗

Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation.Semantic proximity Read ↗

Genomic insights into the comorbidity between type 2 diabetes and schizophreniaSemantic proximity Read ↗

Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects.Semantic proximity Read ↗

Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets.Semantic proximity Read ↗

The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellumSemantic proximity Read ↗

Genomic and transcriptomic insights into antipsychotic-induced changes in total cholesterol and body mass index in a multi-ancestry cohort of the US veteransSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.