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Article

APOE and Cerebral Microbleeds: Insights Into Causal Proteins and Therapeutic Targets.

Brain and behavior - 1 Jun 2026

Yang Lei, Zhao Jian-Lan, Song Jie, Chen Lin-Hui, Yu Chun, Yuan Qiang, Wu Gang, Hu Jin, Wang Mei-Hua

Abstract excerpt

BACKGROUND: Cerebral microbleeds (CMBs) are small chronic brain hemorrhages that can be linked to cognitive decline and stroke risk. Understanding the underlying genetic and proteomic mechanisms can enhance therapeutic interventions. This study aimed to explore the relationship between circulating proteins (cis-pQTLs) and CMBs using Mendelian randomization (MR) and colocalization analysis, along with...

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Share to Apolipoproteins E
Share to Cerebral Hemorrhage
Share to APOE gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Mendelian Randomization Analysis

Share to Protein Interaction Maps

Source

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Identifiers

PMID: 42317103
DOI: 10.1002/brb3.71382
PMCID: PMC13280472

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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