Article
Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.
Nature communications - 17 Oct 2022
Chen Lingyan, Peters James E, Prins Bram, Persyn Elodie, Traylor Matthew, Surendran Praveen, Karthikeyan Savita, Yonova-Doing Ekaterina, Di Angelantonio Emanuele, Roberts David J, Watkins Nicholas A, Ouwehand Willem H, Danesh John, Lewis Cathryn M, Bronson Paola G, Markus Hugh S, Burgess Stephen, Butterworth Adam S, Howson Joanna M M
Abstract excerpt
Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma proteins on stroke outcomes in a two-sample Mendelian randomization framework and assess mediation effects by stroke risk factors. We find associations between genetically predicted plasma levels of six proteins and stroke (P ≤ 1.62 ×...
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