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Article

MCM2 germline variants predispose to familial papillary thyroid carcinoma due to genomic instability caused by MCM complex disruption.

Oncogene - 1 Aug 2026

Cao Shiyu, Ma Tengyun, Zhao Long, Xiao Lin, Zhang Peichuan, Han Yuze, Liu Yichen, Jiang Yong, Ye Feng

Abstract excerpt

In recent years, new cases of thyroid cancer (TC) in China have accounted for about 10% of all newly diagnosed malignant tumors, ranking as the third most common cancer. Familial papillary thyroid carcinoma (fPTC) is a hereditary subtype for which large-scale clinical cohort studies are lacking and definitive susceptibility genes remain elusive. A large fPTC clinical cohort (171 cases), 490 sporadic papillary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42315912
DOI: 10.1038/s41388-026-03846-1

Genes

MCM2
H2AX
MCM3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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