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Article

STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern Papillary Thyroid Cancer.

International journal of molecular sciences - 14 Mar 2026

Bu Rong, Haqawi Wael, Razzaq Eman A Abdul, Azam Saud, Iqbal Kaleem, Qadri Zeeshan, Parvathareddy Sandeep Kumar, Alrasheed Maha, Alobaisi Khadija, Al-Dayel Fouad, Siraj Abdul Khalid, Al-Kuraya Khawla S

Abstract excerpt

Papillary thyroid cancer (PTC) is the most common endocrine malignancy with especially high incidence in Middle Eastern populations. While classical hereditary syndromes explain a minority of cases, the broader germline landscape of non-syndromic PTC remains unclear. Whole-exome sequencing was performed on 245 unselected Saudi PTC patients to identify germline pathogenic or likely pathogenic variants (PVs/LPVs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41898519
DOI: 10.3390/ijms27062656
PMCID: PMC13026885

Genes

STK11
BRCA1
RAD50
TP53
BRCA2
FANCA
MSH6
NF1
POLD1
SLX4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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