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Article

Co-mutations of CTNNB1 and PTEN drive aggressive tumor progression in endometrial cancer.

Disease models & mechanisms - 1 Jul 2026

Nahar Shamsun, Jeong Eunhee M, Kim Keun Cheon, Broaddus Russell, Yoo Jung-Yoon, Jeong Jae-Wook, So Kyeong A, Kim Tae Hoon

Abstract excerpt

Endometrioid endometrial cancer (EEC) is the most prevalent gynecological malignancy. While early-stage EEC typically carries a favorable prognosis, late-stage EEC shows significantly poorer outcomes, with a five-year survival rate of only 17-19%. Co-occurring PTEN and CTNNB1 variants are frequent in EEC and linked to poor prognosis. To investigate their functional impact, we generated uterine-specific Pten...

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Source

Open in PubMed Open full text

Identifiers

PMID: 42312452
DOI: 10.1242/dmm.052788
PMCID: PMC13312928

Genes

CTNNB1
PTEN
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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