Article
Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma.
Journal of the National Cancer Institute - 1 Sept 2014
Liu Yuexin, Patel Lalit, Mills Gordon B, Lu Karen H, Sood Anil K, Ding Li, Kucherlapati Raju, Mardis Elaine R, Levine Douglas A, Shmulevich Ilya, Broaddus Russell R, Zhang Wei
Abstract excerpt
BACKGROUND: Endometrioid endometrial carcinoma (EEC) is the most common form of endometrial carcinoma. The heterogeneous clinical course of EEC is an obstacle to individualized patient care. METHODS: We performed an integrated analysis on the multiple-dimensional data types including whole-exome and RNA sequencing, RPPA profiling, and clinical data from 271 EEC cases in The Cancer Genome Atlas (TCGA) to identify...
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