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Article

Phenotypic and transcriptional changes in human brain pericytes induced by phorbol 12-myristate 13-acetate.

Journal of pharmacological sciences - 1 Aug 2026

Miyake Yudai, Tanabe Shogo, Yonezu Yoshino, Misawa Hidemi, Muramatsu Rieko

Abstract excerpt

Pericytes are multifunctional mural cells that contribute to vascular stability, inflammation, and fibrosis in the central nervous system. Phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), is widely used to induce cellular activation and inflammatory responses in various cell types. In this study, we investigated how PMA affects human brain pericyte phenotypes and gene...

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Identifiers

PMID: 42303345
DOI: 10.1016/j.jphs.2026.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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