Article
V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Acta neuropathologica communications - 18 May 2016
Valls Serón Mercedes, Ferwerda Bart, Engelen-Lee JooYeon, Geldhoff Madelijn, Jaspers Valery, Zwinderman Aeilko H, Tanck Michael W, Baas Frank, van der Ende Arie, Brouwer Matthijs C, van de Beek Diederik
Abstract excerpt
Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Here, we have performed a prospective nationwide genetic association study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 (DCTN4), retinoic acid early transcript 1E (RAET1E), and V-akt murine thymoma viral...
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