Article
A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
Disease models & mechanisms - 1 Aug 2014
Sievert Henning, Pällmann Nora, Miller Katharine K, Hermans-Borgmeyer Irm, Venz Simone, Sendoel Ataman, Preukschas Michael, Schweizer Michaela, Boettcher Steffen, Janiesch P Christoph, Streichert Thomas, Walther Reinhard, Hengartner Michael O, Manz Markus G, Brümmendorf Tim H, Bokemeyer Carsten, Braig Melanie, Hauber Joachim, Duncan Kent E, Balabanov Stefan
Abstract excerpt
The central importance of translational control by post-translational modification has spurred major interest in regulatory pathways that control translation. One such pathway uniquely adds hypusine to eukaryotic initiation factor 5A (eIF5A), and thereby affects protein synthesis and, subsequently, cellular proliferation through an unknown mechanism. Using a novel conditional knockout mouse model and a...
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