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Exploiting amplification byproducts to enable colorimetric ctDNA detection via nanozyme inhibition.

Biosensors & bioelectronics - 1 Nov 2026

Yuan Xiaohua, Liu Lianhua, He Xun, Tang Hong, Zhang Limei, Zhu Shuairu, Cui Wanding, Luo Fengming, Shakir Imran, Ying Binwu, Sun Xuping, Zhou Juan

Abstract excerpt

Sensitive circulating tumor DNA (ctDNA) analysis is increasingly important for mutation monitoring and molecular stratification in cancer management, yet most current approaches depend on complex signal transducers, fluorescent labels and sophisticated instrumentation. Here, we present an amplification byproduct-induced nanozyme suppression (ABINS) strategy that uses amplification byproducts as functional signals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42296807
DOI: 10.1016/j.bios.2026.118925

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KRAS

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