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Article

Mismatch-Guided Deoxyribonucleic Acid Assembly Enables Ultrasensitive and Multiplex Detection of Low-Allele-Fraction Variants in Clinical Samples.

Journal of the American Chemical Society - 20 Sept 2023

Huang Dan, Deng Hui, Zhou Juan, Wang Guan A, Lei Qian, Guo Chen, Peng Wanting, Liang Peng, Shen Chenlan, Ying Binwu, Li Weimin, Li Feng

Abstract excerpt

Somatic mutations are important signatures in clinical cancer treatment. However, accurate detection of rare somatic mutations with low variant-allele frequencies (VAFs) in clinical samples is challenging because of the interference caused by high concentrations of wild-type (WT) sequences. Here, we report a post amplification SNV-specific DNA assembly (PANDA) technology that eliminates the high concentration...

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PMID: 37651106
DOI: 10.1021/jacs.3c05879

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