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Article

Nanopore Identification of Single Nucleotide Mutations in Circulating Tumor DNA by Multiplexed Ligation.

Clinical chemistry - 29 Apr 2021

Burck Nitza, Gilboa Tal, Gadi Abhilash, Patkin Nehrer Michelle, Schneider Robert J, Meller Amit

Abstract excerpt

BACKGROUND: Circulating tumor DNAs (ctDNAs) are highly promising cancer biomarkers, potentially applicable for noninvasive liquid biopsy and disease monitoring. However, to date, sequencing of ctDNAs has proven to be challenging primarily due to small sample size and high background of fragmented cell-free DNAs (cfDNAs) derived from normal cells in the circulation, specifically in early stage cancer. METHODS:...

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Identifiers

PMID: 33496315
DOI: 10.1093/clinchem/hvaa328
PMCID: PMC7617058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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