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DNAzyme-powered autocatalytic cascade MnO2 nanodevice for ultrasensitive in situ profiling of circulating tumor cell phenotypes.

Talanta - 1 Oct 2026

Peng Shaoyun, Lin Chiliang, Tang Yong, He Junling, Zhou Chen, Zou Haimin

Abstract excerpt

Circulating tumor cells (CTCs), recognized as critical biomarkers of tumor metastasis, play a pivotal role in monitoring cancer progression and improving prognosis. However, the phenotypic and morphological heterogeneity of CTCs often leads to compromised enrichment efficiency, posing significant challenges for reliable detection and phenotypic identification. To address these limitations, we developed a MnO2...

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PMID: 42105518
DOI: 10.1016/j.talanta.2026.129953

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