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Article

Clamp the LAMP: a photoelectrochemical platform for KRAS mutation detection via wild-type blocking.

Biosensors & bioelectronics - 15 Jul 2026

Strmiskova J, Valverde A, Moranova L, Arnouts J, Zavadil-Kokas F, Koljenovic S, Zwaenepoel K, Vandamme T, Bartosik M, De Wael K

Abstract excerpt

KRAS mutations are among the most prevalent oncogenic alterations in colorectal, lung and pancreatic cancer, yet their detection remains analytically challenging in the presence of an overwhelming wild-type (WT) background. Here, we report a photoelectrochemical (PEC) genotyping platform that integrates clamp-inhibited loop-mediated isothermal amplification (C-LAMP) with enzyme-free singlet oxygen (1O2)-driven...

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Identifiers

PMID: 41855941
DOI: 10.1016/j.bios.2026.118617

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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