Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of IL7R as a key genetic risk locus in childhood steroid-sensitive nephrotic syndrome and IgA nephropathy.

Frontiers in immunology - 1 Jan 2026

Wang Cong, Jiang Yue, Song Yingchao, Tian Minle, Wang Xiaoyuan, Wang Jing, Li Qian, Zang Ruixian, Yang Zhenle, Yu Lichun, Liu Suwen, Wang Li, Yao Xiujun, Zhou Aihua, Yu Hongwei, Ullah Kalim, Glessner Joseph, Hakonarson Hakon, Sun Shuzhen, Chang Xiao

Abstract excerpt

Introduction: Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is a common childhood glomerular disorder characterized by corticosteroid responsiveness, yet frequent relapses and steroid dependence lead to long-term complications. While GWAS have identified genetic risk loci for pSSNS, its shared genetic architecture with immune-mediated glomerulopathies like IgA nephropathy (IgAN) remains unclear. Methods:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Glomerulonephritis, IGA

Share to Interleukin-7 Receptor alpha Subunit

Share to Nephrotic Syndrome

Share to Receptors, Interleukin-7

Source

Open in PubMed Open full text

Identifiers

PMID: 42292351
DOI: 10.3389/fimmu.2026.1806680
PMCID: PMC13260247

Genes

IL7R
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of IL7R as a key genetic risk locus in childhood steroid-sensitive nephrotic syndrome and IgA nephropathy.PMID 42292351Read ↗

Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.Semantic proximity Read ↗

An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome.Semantic proximity Read ↗

GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid-Sensitive Nephrotic SyndromeSemantic proximity Read ↗

Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndromeSemantic proximity Read ↗

Polygenic risk score from steroid-sensitive nephrotic syndrome GWAS indicates overlapping genetic basis with steroid-resistant cases.Semantic proximity Read ↗

Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome.Semantic proximity Read ↗

Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.Semantic proximity Read ↗

Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An UpdateSemantic proximity Read ↗

Polygenic risk scores and HLA class II variants are biomarkers of corticosteroid response in childhood nephrotic syndrome.Semantic proximity Read ↗

Polygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic SyndromeSemantic proximity Read ↗

Genetics of childhood steroid-sensitive nephrotic syndrome.Semantic proximity Read ↗

Toward personalized medicine in childhood nephrotic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.