Article
Genetics of childhood steroid-sensitive nephrotic syndrome.
Pediatric nephrology (Berlin, Germany) - 1 Sept 2017
Karp Alana M, Gbadegesin Rasheed A
Abstract excerpt
The pathogenesis of childhood-onset nephrotic syndrome (NS), disparity in incidence of NS among races, and variable responses to therapies in children with NS have defied explanation to date. In the last 20 years over 50 genetic causes of steroid-resistant nephrotic syndrome (SRNS) have been identified, and at least two disease loci for two pathologic variants of SRNS (focal segmental glomerulosclerosis and...
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