Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.

doi:10.1681/ASN.2018101054

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Article

Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.

Journal of the American Society of Nephrology : JASN - 1 Aug 2019

Dufek Stephanie, Cheshire Chris, Levine Adam P, Trompeter Richard S, Issler Naomi, Stubbs Matthew, Mozere Monika, Gupta Sanjana, Klootwijk Enriko, Patel Vaksha, Hothi Daljit, Waters Aoife, Webb Hazel, Tullus Kjell, Jenkins Lucy, Godinho Lighta, Levtchenko Elena, Wetzels Jack, Knoers Nine, Teeninga Nynke, Nauta Jeroen, Shalaby Mohamed, Eldesoky Sherif, Kari Jameela A, Thalgahagoda Shenal, Ranawaka Randula, Abeyagunawardena Asiri, Adeyemo Adebowale, Kristiansen Mark, Gbadegesin Rasheed, Webb Nicholas J, Gale Daniel P, Stanescu Horia C, Kleta Robert, Bockenhauer Detlef

Abstract excerpt

BACKGROUND: Steroid-sensitive nephrotic syndrome (SSNS), the most common form of nephrotic syndrome in childhood, is considered an autoimmune disease with an established classic HLA association. However, the precise etiology of the disease is unclear. In other autoimmune diseases, the identification of loci outside the classic HLA region by genome-wide association studies (GWAS) has provided critical insights...

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PMID: 31263063
DOI: 10.1681/ASN.2018101054
PMCID: PMC6683715

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CALHM6

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