Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβ.

Redox biology - 1 Sept 2026

Jiang Yuanqing, Li Yi, Ma Kefan, Guo Suxiang, Liao Nachuan, Zhou Jiayi, Chen Junbo, Ren Ruizhe, Kou Yaohui, Li Jinying, Liu He, Wei Yang, Zhou Xiaofei, Fan Linge, Qin Lingfeng, Zhao Haige, Xiao Ying, Yu Luyang, Ge Zhen, Qiu Cong

Abstract excerpt

Atherosclerotic plaque rupture is the leading cause of most acute cardiovascular events and death. However, effective treatment strategies targeting plaque stability remain elusive. Perivascular adipose tissue (PVAT) dysfunction is increasingly recognized as a contributor to vulnerable plaque, implying that elucidating and targeting its underlying mechanism could represent a novel therapeutic strategy for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Protein-beta

Share to Dioxoles

Share to Ferroptosis

Share to Gene Expression Regulation

Share to Plaque, Atherosclerotic

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 42289168
DOI: 10.1016/j.redox.2026.104259
PMCID: PMC13279912

Genes

GPX4
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβ.PMID 42289168Read ↗

Transcription factor EB, a promising therapeutic target in cardiovascular diseaseSemantic proximity Read ↗

Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosisSemantic proximity Read ↗

Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis.Semantic proximity Read ↗

Endoplasmic Reticulum Stress Impairs Macrophage Efferocytosis via TRIB3-Rab27a Signaling and Exacerbates Atherosclerotic Plaque NecrosisSemantic proximity Read ↗

Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions.Semantic proximity Read ↗

Atherosclerotic Plaque Instability and Rupture: Recommended Mouse Models to Empower Clinically Relevant Discoveries, Diagnostics, and Therapeutics.Semantic proximity Read ↗

Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease MyopathySemantic proximity Read ↗

Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability.Semantic proximity Read ↗

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.Semantic proximity Read ↗

Postoperative Stress Accelerates Atherosclerosis through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol TransportSemantic proximity Read ↗

The microenvironment of the atheroma expresses phenotypes of plaque instability.Semantic proximity Read ↗

Characterization of plaque phenotypes exhibiting an elevated pericoronary adipose tissue attenuation: insights from the REASSURE-NIRS registry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.