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Article

Pan-cancer whole-genome comparison of primary and metastatic solid tumours.

Nature - 1 Jun 2023

Martínez-Jiménez Francisco, Movasati Ali, Brunner Sascha Remy, Nguyen Luan, Priestley Peter, Cuppen Edwin, Van Hoeck Arne

Abstract excerpt

Metastatic cancer remains an almost inevitably lethal disease1-3. A better understanding of disease progression and response to therapies therefore remains of utmost importance. Here we characterize the genomic differences between early-stage untreated primary tumours and late-stage treated metastatic tumours using a harmonized pan-cancer analysis (or reanalysis) of two unpaired primary4 and metastatic5 cohorts...

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Identifiers

PMID: 37165194
DOI: 10.1038/s41586-023-06054-z
PMCID: PMC10247378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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