Article
Systematic perturbation of cytoskeletal function reveals a linear scaling relationship between cell geometry and fitness.
Cell reports - 20 Nov 2014
Monds Russell D, Lee Timothy K, Colavin Alexandre, Ursell Tristan, Quan Selwyn, Cooper Tim F, Huang Kerwyn Casey
Abstract excerpt
Diversification of cell size is hypothesized to have occurred through a process of evolutionary optimization, but direct demonstrations of causal relationships between cell geometry and fitness are lacking. Here, we identify a mutation from a laboratory-evolved bacterium that dramatically increases cell size through cytoskeletal perturbation and confers a large fitness advantage. We engineer a library of...
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