Article
Systematic identification of pathways that couple cell growth and division in yeast.
Science (New York, N.Y.) - 19 Jul 2002
Jorgensen Paul, Nishikawa Joy L, Breitkreutz Bobby-Joe, Tyers Mike
Abstract excerpt
Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in the late prereplicative growth phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of approximately 6000 Saccharomyces cerevisiae gene deletion strains and identified approximately 500 abnormally small (whi) or large (lge) mutants. Genetic analysis...
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