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Article

KRASG12C Can Either Promote or Impair Cap-Dependent Translation in Two Different Lung Adenocarcinoma Cell Lines.

International journal of molecular sciences - 23 Feb 2021

Kyriakopoulos George, Katopodi Vicky, Skeparnias Ilias, Kaliatsi Eleni G, Grafanaki Katerina, Stathopoulos Constantinos

Abstract excerpt

KRASG12C is among the most common oncogenic mutations in lung adenocarcinoma and a promising target for treatment by small-molecule inhibitors. KRAS oncogenic signaling is responsible for modulation of tumor microenvironment, with translation factors being among the most prominent deregulated targets. In the present study, we used TALENs to edit EGFRWT CL1-5 and A549 cells for integration of a Tet-inducible...

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PMID: 33672357
DOI: 10.3390/ijms22042222
PMCID: PMC7926983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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