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An integrative mutational and network analysis of pancreatic cancer reveals key genes, and signalling pathways.

Functional & integrative genomics - 12 Jun 2026

Manjunath Gowrang Kasaba, Kanchi Lasya Priya, Dakal Tikam Chand, Beura Abhijit, Kumar Abhishek

Abstract excerpt

Pancreatic cancer (PC) is one of the most lethal malignancies, with an approximately 5% 5-year survival rate. Understanding the intricate network of interactions among the proteins of key pathways is critical for assessing the PC prognosis. Herein, we have carried out a systematic approach by collecting mutational data of genes involved in 10 PC studies with 6,325 PC samples from cBioPortal. A total of 15,088...

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Source

Identifiers

PMID: 42277390
DOI: 10.1007/s10142-026-01921-0

Genes

PC
KRAS
SMAD4
TP53
ACVR1B
ARID1A
CDKN2A
FLG
MUC16
NF1
RBBP8
RNF43
STK11
TSC1
TSC2
TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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