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Article

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.

Cancer cell - 14 Aug 2017

Abstract excerpt

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers,...

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Topics

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Share to Carcinoma, Pancreatic Ductal
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Pancreatic Neoplasms

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Source

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Identifiers

PMID: 28810144
DOI: 10.1016/j.ccell.2017.07.007
PMCID: PMC5964983

Genes

KRAS
GNAS
BRAF
CTNNB1
MTOR
PBRM1
RNF43
SMAD4

Provenance

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