Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts May be Clinically Relevant?

doi:10.1016/j.soc.2015.11.003

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Article

Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts May be Clinically Relevant?

Surgical oncology clinics of North America - 1 Apr 2016

Bernard Vincent, Fleming Jason, Maitra Anirban

Abstract excerpt

Carcinogenic progression in the pancreas arises through a well-established stepwise accumulation of molecular aberrations from a normal cell to an invasive adenocarcinoma. Recent large-scale sequencing efforts have provided insight into novel driver genes as well as enriched core signaling pathways that underlie the inherent heterogeneity found in pancreatic cancer. By exploiting these genomic profiles, we may...

Topics

Adenocarcinoma
Carcinogenesis
Carcinoma, Pancreatic Ductal
Disease Progression
Gene Expression Profiling
Humans
Mutation
Signal Transduction

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Open in PubMed

Identifiers

PMID: 27013361
DOI: 10.1016/j.soc.2015.11.003

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