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Article

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

25 Jun 2015

Abstract excerpt

Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric repeats and recruits a series of additional factors that are essential for telomere function. Although many shelterin-associated proteins have been so far...

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PMID: 26110528
DOI: 10.1371/journal.pgen.1005167

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