Article
Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction.
American heart journal - 1 Jul 2003
Iwai Chikao, Akita Hozuka, Kanazawa Kenji, Shiga Nobuyuki, Terashima Masahiro, Matsuda Yasuaki, Takai Eiji, Miyamoto Yoshitomo, Shimizu Masakatsu, Kajiya Teishi, Hayashi Takatoshi, Yokoyama Mitsuhiro
Abstract excerpt
BACKGROUND: We sought to investigate the relation between the Arg389Gly polymorphism in the human beta1-adrenergic receptor (ADRB1) gene and acute myocardial infarction (AMI). It was previously reported that augmented sympathetic activity might play an important role as a trigger of AMI by enhanced hemodynamic or mechanical forces through ADRB1 activation. Recently, a common polymorphism has been identified at...
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