Mutation-biased adaptation is consequential even in large bacterial populations.

Abstract excerpt

Because mutation rates vary widely across genomes and environments, natural selection is typically presented with highly biased variation. Yet, the idea that mutational tendencies can influence adaptation is still controversial. While mutation-driven adaptation has been observed in diverse taxa, critics contend it reflects small populations or weak-effect mutations. Therefore, the importance and generality of...

Topics

• Escherichia coli
• Mutation
• Selection, Genetic
• Adaptation, Physiological
• Anti-Bacterial Agents
• Models, Genetic
• Mutation Rate
• Drug Resistance, Bacterial
• Evolution, Molecular
• Computer Simulation