Article
Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution.
Nature ecology & evolution - 1 Apr 2022
Schenk Martijn F, Zwart Mark P, Hwang Sungmin, Ruelens Philip, Severing Edouard, Krug Joachim, de Visser J Arjan G M
Abstract excerpt
Mutations with large fitness benefits and mutations occurring at high rates may both cause parallel evolution, but their contribution is predicted to depend on population size. Moreover, high-rate and large-benefit mutations may have different long-term adaptive consequences. We show that small and 100-fold larger bacterial populations evolve resistance to a β-lactam antibiotic by using similar numbers, but...
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