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Article

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Jul 2009

Saha Shamol, Guillily Maria D, Ferree Andrew, Lanceta Joel, Chan Diane, Ghosh Joy, Hsu Cindy H, Segal Lilach, Raghavan Kesav, Matsumoto Kunihiro, Hisamoto Naoki, Kuwahara Tomoki, Iwatsubo Takeshi, Moore Landon, Goldstein Lee, Cookson Mark, Wolozin Benjamin

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant familial Parkinson's disease. We generated lines of Caenorhabditis elegans expressing neuronally directed human LRRK2. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are agent...

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Identifiers

PMID: 19625511
DOI: 10.1523/JNEUROSCI.2281-09.2009
PMCID: PMC3127548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19625511-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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