Article
Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19.
Clinical pharmacology and therapeutics - 1 Jul 2001
Wang J H, Liu Z Q, Wang W, Chen X P, Shu Y, He N, Zhou H H
Abstract excerpt
OBJECTIVE: Our objective was to evaluate the relationship between the disposition of sertraline and the presence of the CYP2C19 gene and to define the contribution of cytochrome P450 2C19 (CYP2C19) to sertraline N-demethylation. METHODS: A single oral 100-mg dose of sertraline was administered to 6 subjects who were extensive metabolizers and 6 subjects who were poor metabolizers recruited from 77 healthy Chinese...
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